Medication that inhibit CYP2D6 activity, such as paroxetine and quinidine, may induce reduced clearance of oxycodone which may lead to an increase in oxycodone plasma concentrations. Concurrent administration of quinidine resulted in an increase in oxycodone Cmax by 11%, AUC by 13%, and t½ elim.Breastfeeding Administration to nursing Women of all

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